Posts Tagged ‘PD’

Are musculoskeletal problems in Parkinson’s disease neglected

Parkinson’s disease – PD patients do not receive adequate treatment for musculoskeletal problems. This was the conclusion reached by Kim YE et al. from the Department of Neurology and Movement Disorder Center, Parkinson Study Group, Seoul National University Hospital, Seoul, Republic of Korea.

The researches found the prevalence of musculoskeletal problems was significantly higher in the Parkinson disease (PD) group compared to controls. However these musculoskeletal problems in the PD group tended to receive less treatment than that of the control group despite PD patients having a higher prevalence than in the controls.

White Matter Changes Correlate with Cognitive Functioning in Parkinsons Disease

Diffusion tensor imaging (DTI) can be used to see cortical white-matter integrity in Parkinson’s disease (PD).

Writing in Frontiers in Neurology, 05/02/2013 Theilmann RJ et al from Neurology Service VA San Diego Healthcare System and the Department of Neuroscience, University of California San Diego, USA  show that abnormal tissue diffusivity may be sensitive to cognitive changes and cognitive decline in PD. These changes may be of prognostic use in the future.   Motor symptom severity did not correlate to abnormal tissue diffusivity.

Dual task and walking in PD patients

Everyday walking typically takes place in an environments that demands the allocation of attention between gait and a simultaneously-performed a tasks. Examples of this include walking and talking on a cellphone. This can be compared to single task walking. DT walking ability more closely reflects the functional daily living walking task.  Healthy young adults walk and perform other tasks with little impact on their gait. However, when gait is impaired then performing a DT will cause changes in the walking pattern. This is shown is some PD patients where e simultaneous performance of a

DT generally causes patients with PD to walk more slowly, with shorter strides, and with a much larger effect of the DT on gait than seen in healthy controls

FMRI and insights into degeneration of dopaminergic neurons in the substantia nigra in Parkinson’s disease

Parkinson’s disease PD results in motor, cognitive, sensory and affective deficits that lead to movement impairment. The mechanism is a degeneration of dopaminergic neurons in the substantia nigra. Dr. van der Vegt JP et al Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Denmark present in Brain, 04/04/2013 present evidence that suggests that these deficits are not due to the contaminating effect of dopaminergic treatment. The team do this by testing drug-naive patients with Parkinson’s disease who underwent whole-brain functional magnetic resonance imaging. They show that the core regions of the meso–cortico–limbic dopaminergic system, including the ventral tegmental area, ventral striatum, and medial orbitofrontal cortex, are already significantly compromised in the early stages of Parkinson’s disease PD.


Clinical freezing of Gait in Parkinson’s Disease

Using  timed ‘up and go’ tasks on together with functional magnetic resonance imaging on parkinsons disease patients has allowed Dr.Shine from the Parkinson’s Disease Research Clinic, Brain and Mind Research Institute to present insights into  the pathophysiology underlying freezing of gait which limits functional walking ability in advanced Parkinson’s disease PD patients. The team are from the University of Sydney, NSW 2050, Australia.

Mechanism for development of involuntary movements in Parkinsons disease PD patients

Writing in Cerebral Cortex, 04/02/2013, Dr. Kishore A et al dicuss how abnormal involuntary movements and cerebellar sensory processing function dysfunction in Parkinsons disease PD patients may be a result of maladaptive sensorimotor plasticity of M1 due to abnormal basal ganglia signals reaching it. The group are from Comprehensive Care Centre for Movement Disorders, Department of Neurology,  Medical Sciences and Technology, Kerala India.

Exercise practice reduces disability and improves quality of life in Parkinson disease (PD)

Published in Physical Therapy, 03/15/2013 Dr. Ellis and team from Department of Physical Therapy and Athletic Training, Sargent College of Health and Rehabilitation Sciences, Boston University, USA discuss the benefits of exercise therapy in chronic progressive neurological diseases, such as PD. Exercise is known to reduce disability and improve quality of life in people with Parkinson disease (PD). Several factors however prevent compliance with exercise therapy including lack of time to exercise, and fear of falling. The group conclude that strategies to facilitate exercise adherence in people with PD in an ambulatory community dwelling need to be developed.

The HandTutor and ArmTutor for upper limb movement impairment exercise training support tele rehabilitation which is motivating for the patient to continue exercise practice.