Posts Tagged ‘Parkinsons disease’

Are musculoskeletal problems in Parkinson’s disease neglected

Parkinson’s disease – PD patients do not receive adequate treatment for musculoskeletal problems. This was the conclusion reached by Kim YE et al. from the Department of Neurology and Movement Disorder Center, Parkinson Study Group, Seoul National University Hospital, Seoul, Republic of Korea.

The researches found the prevalence of musculoskeletal problems was significantly higher in the Parkinson disease (PD) group compared to controls. However these musculoskeletal problems in the PD group tended to receive less treatment than that of the control group despite PD patients having a higher prevalence than in the controls.

White Matter Changes Correlate with Cognitive Functioning in Parkinsons Disease

Diffusion tensor imaging (DTI) can be used to see cortical white-matter integrity in Parkinson’s disease (PD).

Writing in Frontiers in Neurology, 05/02/2013 Theilmann RJ et al from Neurology Service VA San Diego Healthcare System and the Department of Neuroscience, University of California San Diego, USA  show that abnormal tissue diffusivity may be sensitive to cognitive changes and cognitive decline in PD. These changes may be of prognostic use in the future.   Motor symptom severity did not correlate to abnormal tissue diffusivity.

FMRI and insights into degeneration of dopaminergic neurons in the substantia nigra in Parkinson’s disease

Parkinson’s disease PD results in motor, cognitive, sensory and affective deficits that lead to movement impairment. The mechanism is a degeneration of dopaminergic neurons in the substantia nigra. Dr. van der Vegt JP et al Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Denmark present in Brain, 04/04/2013 present evidence that suggests that these deficits are not due to the contaminating effect of dopaminergic treatment. The team do this by testing drug-naive patients with Parkinson’s disease who underwent whole-brain functional magnetic resonance imaging. They show that the core regions of the meso–cortico–limbic dopaminergic system, including the ventral tegmental area, ventral striatum, and medial orbitofrontal cortex, are already significantly compromised in the early stages of Parkinson’s disease PD.


Hip fracture in Parkinson’s disease (PD)

Published in Movement Disorders, 02/26/2013 Dr. Walker compares the incidence and outcomes of Parkinson’s disease (PD) who suffer hip fracture compared to non PD patients in North East England. The team from the Department of Medicine, North Tyneside General Hospital, United Kingdom saw that PD patients had poorer mobility before hip fracture, had less mobility post surgery and took longer to be discharged into community physical rehabilitation. The team concludes that occupational and physiotherapists managing people with PD who sustain a hip fracture should be aware of potential complications of the condition to improve physical rehabilitation outcomes.

Neurostimulation as a treatment for motor dysfunction in Parkinson’s disease

Published in the New England Journal of medicine- Dr. Deuschl  – Department of Neurology, University Hospital Schleswig–Holstein, Campus Kiel discuss neurostimulation as an established treatment for advanced Parkinson’s disease. The group also show how neurostimulation for Parkinson’s Disease patients with Early Motor Complications also results in an improvement of functional ability.

The group looked at quality of life at 2 years post treatment using the Parkinson’s Disease Questionnaire (PDQ-39) as well as the secondary outcomes of Parkinsonian motor disability, activities of daily living, levodopa-induced motor complications, and time with good mobility and no dyskinesia.

Nonmotor symptoms and Parkinsons disease

Writing in neurology Jan 2013, Dr. Khoo et al study the frequency of non motor symptoms in early PD.  Dr. Khoo team consisted of scientists and physical and occupational therapists from Newcastle University, Newcastle upon Tyne; Imperial College, MRC Clinical Sciences Centre, London; and Cambridge Centre for Brain Repair (Cambridge University, Cambridge, UK.

Because Nonmotor symptoms (NMS) are common in patients with established Parkinson disease (PD) the team determined the frequency of NMS in newly diagnosed PD patients. The most common NMS symptoms were excessive saliva, forgetfulness, urinary urgency, hyposmia, and constipation and even in the early stages of PD, NMS is detrimental to patients’ functional status and quality of life and sense of well being.


Assistive technology imjproves walking in neurological disease and injury

Assistive technology assists walking

Writing in the January edition of disability Rehabilitation Dr. Wittwer and his group from Trobe University, Melbourne, Australia; Department of Physiotherapy look at clinical trials that assess assistive rehabilitation technologies that synchronise over-ground walking to rhythmic auditory cues. The objective is to improve temporal and spatial gait measures in adults with neurological clinical conditions and improve walking. The group found that this technology will result in a short-term improvement in gait in patient groups including stroke, Huntington’s disease, spinal cord injury, traumatic brain injury, dementia, multiple sclerosis and parkinson’s disease.