Posts Tagged ‘Basal ganglia’

The contribution of movement activation and inhibition in Parkinson’s Disease

Writing in Journal of Parkinson’s Disease, 05/08/2013 Disbrow EA et al.use functional magnetic resonance imaging (fmri) to look at  circuits within the basal ganglia that coordinate activation and inhibition involved in action selection as well as execution in PD patients. The researchers are from the VA Northern California Health Care System, CA, USA and the Department of Neurology, UC Davis, CA, USA.



Neurosteroids as neuroprotectants for the treatment of Parkinsons disease (PD)

Parkinson’s disease (PD) is associated with a massive loss of dopaminergic cells in the substantia nigra leading to dopamine hypofunction and alteration of the basal ganglia circuitry. Writing in Experimental Neurologydi Michele F et al from Fondazione Santa Lucia, Rome, Italy reviews the roles of Neurosteroids – NS acting as neuroprotectants and as GABAA receptor agonists in the physiology and pathophysiology of the basal ganglia. He looks at their impact on dopaminergic cell activity and survival. The review article then considers their potential therapeutic application in PD.

Mechanism for development of involuntary movements in Parkinsons disease PD patients

Writing in Cerebral Cortex, 04/02/2013, Dr. Kishore A et al dicuss how abnormal involuntary movements and cerebellar sensory processing function dysfunction in Parkinsons disease PD patients may be a result of maladaptive sensorimotor plasticity of M1 due to abnormal basal ganglia signals reaching it. The group are from Comprehensive Care Centre for Movement Disorders, Department of Neurology,  Medical Sciences and Technology, Kerala India.

Anatomy Underlying Acute vs Chronic Spatial Neglect

Author - John Henkel, from the Food and Drug A...

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In the January issue of Brain A journal of Neurology, Dr. Hans-Otto Karnath and his team at University of Tübingen Germany investigate The anatomy underlying acute versus chronic spatial neglect: a longitudinal study
Acute brain imaging (acquired on average 6.2 days post-injury) was used to evaluate neglect symptoms at the initial (mean 12.4 days post-stroke) and the chronic (mean 491 days) phase of the stroke. Chronic neglect was found in about one-third of the patients with acute neglect.
The team’s findings infer that individuals who experience spatial neglect in the initial phase of the stroke yet do not have injury to cortical including the superior and middle temporal gyri and sub-cortical including basal ganglia and inferior occipitofrontal fasciculus/extreme are likely to recover, and thus have a favorable prognosis.

The HandTutor system has virtual tasks that purposely draw the patient’s attention to the right and left side of the screen during exercise practice. This gives the patient augmented feedback and stimulation in these areas of the screen.