White Matter Changes Correlate with Cognitive Functioning in Parkinsons Disease

Diffusion tensor imaging (DTI) can be used to see cortical white-matter integrity in Parkinson’s disease (PD).

Writing in Frontiers in Neurology, 05/02/2013 Theilmann RJ et al from Neurology Service VA San Diego Healthcare System and the Department of Neuroscience, University of California San Diego, USA  show that abnormal tissue diffusivity may be sensitive to cognitive changes and cognitive decline in PD. These changes may be of prognostic use in the future.   Motor symptom severity did not correlate to abnormal tissue diffusivity.

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