Neurosteroids as neuroprotectants for the treatment of Parkinsons disease (PD)

Parkinson’s disease (PD) is associated with a massive loss of dopaminergic cells in the substantia nigra leading to dopamine hypofunction and alteration of the basal ganglia circuitry. Writing in Experimental Neurologydi Michele F et al from Fondazione Santa Lucia, Rome, Italy reviews the roles of Neurosteroids – NS acting as neuroprotectants and as GABAA receptor agonists in the physiology and pathophysiology of the basal ganglia. He looks at their impact on dopaminergic cell activity and survival. The review article then considers their potential therapeutic application in PD.


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: