Neurosteroids as neuroprotectants for the treatment of Parkinsons disease (PD)

Parkinson’s disease (PD) is associated with a massive loss of dopaminergic cells in the substantia nigra leading to dopamine hypofunction and alteration of the basal ganglia circuitry. Writing in Experimental Neurologydi Michele F et al from Fondazione Santa Lucia, Rome, Italy reviews the roles of Neurosteroids – NS acting as neuroprotectants and as GABAA receptor agonists in the physiology and pathophysiology of the basal ganglia. He looks at their impact on dopaminergic cell activity and survival. The review article then considers their potential therapeutic application in PD.

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