Sinemet and Madopar Does Not Accelerate Parkinson’s Disease Progression

Reported on November 2011 for the National Parkinson’s Foundation to the Parkinson’s Disease Community
Dr. Michael S. Okun the NPF’s National Medical Director talks to Parkinson’s disease (PD) patients and families members have been unnecessarily alarmed by the continuing reports that Sinemet and/or Madopar (European Sinemet) may accelerate disease progression. Sinemet and Madopar should be considered safe and effective as treatments for Parkinson’s disease.
Michael says that these reports have been accelerated relatively little clinical evidence and PD patients need to know that dopamine replacement therapies such as Sinemet and Madopar are the  single most effective, and important treatment for Parkinson’s disease.
This is confirmed by the November edition of Neurology that presents evidence that dopamine replacement therapy is not toxic, does not accelerate disease progression.  The issue also talks on the issue of  whether dopamine therapy accelerates PD progression and said that the evidence does not show toxicity of the drug in the human form of Parkinson’s disease.  Indeed, evidence from many studies (including the recent ELLDOPA study shows that levodopa is extremely beneficial to the human patient, and levodopa has a positive effect on disease course.
The physiotherapy that is used by Parkinson’s patients should include the Tutor System.
Although there is no known cure for Parkinson’sdisease there is help to alleviate some of the symptoms.  The HandTutor, ArmTutor, LegTutor and 3DTutor devices are being used successfully in a number of U.S. and foreign hospitals  as well as physical therapy clinics and in the patient’s own home using tele rehabilitation.
The newly developed  Tutor devices  including the HandTutor, ArmTutor, LegTutor provide encouraged and customized exercise practice.  If PD if you don’t use the lower and upper limb as much as possible you will more quickly loose movement ability in arm and legs. Therefore the HandTutor, ArmTutor, LegTutor has become a key system in neuromuscular rehabilitation and physical therapy. These innovative devices implement an impairment based program with augmented feedback and encourage motor learning through intensive active exercises. These exercises are challenging and motivating and allow physical and occupational therapists to prescribe to their patients exercise practice that is intensive and repetitive training tailored to the patient’s performance. The Tutor system also includes objective quantitative evaluations that provide the therapist information to customize the most suitable rehabilitation program to the patient’s ability.  See

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